Invention Grant
- Patent Title: Swellable dosage form comprising gellan gum
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Application No.: US13212679Application Date: 2011-08-18
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Publication No.: US08383155B2Publication Date: 2013-02-26
- Inventor: Daniel Bar-Shalom , Lillian Slot , Gina Fischer , Pernille Høyrup Hemmingsen
- Applicant: Daniel Bar-Shalom , Lillian Slot , Gina Fischer , Pernille Høyrup Hemmingsen
- Applicant Address: DK Vaerlose
- Assignee: Egalet A/S
- Current Assignee: Egalet A/S
- Current Assignee Address: DK Vaerlose
- Agency: Foley & Lardner LLP
- Priority: DK200400755 20040511
- Main IPC: A61K8/02
- IPC: A61K8/02 ; A61K9/48 ; A61K31/546 ; A61K31/44 ; A61K31/295 ; A61K31/715 ; A61K8/00 ; A61K31/167 ; A61K9/00 ; A61K31/192 ; A61Q1/00 ; A61Q11/00 ; A61P43/00 ; A61P29/00

Abstract:
A novel dosage form. The dosage form is presented in particulate form and before oral ingestion the particulate material is subjected to an aqueous medium, whereby it is converted to a semi-solid form by swelling or gelling of one or more of the components, especially of a gellan gum, of the particulate matter. The invention also relates to a vehicle for oral administration of one or more active substances, the vehicle comprising a gellan gum arranged in a configuration allowing optimal water diffusion so that upon addition of a predetermined amount of an aqueous medium, without the necessity of applying shear forces or other mixing forces, within a time period of 5 minutes or less swells and/or gels and the texture of the swelled vehicle being similar to that of a soft pudding and having a viscosity of at least about 10,000 cps as measured by a Brookfield Viscometer with a #4 LV spindle at 6 rpm and at 20-25° C. In one embodiment of the invention, the particulate matter can be molded into a desired shape or pressed onto a dispensing unit such as a spoon.
Public/Granted literature
- US20120039969A1 SWELLABLE DOSAGE FORM COMPRISING GELLAN GUM Public/Granted day:2012-02-16
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