Invention Grant
- Patent Title: Method for non-invasive prenatal diagnosis
- Patent Title (中): 非侵入性产前诊断方法
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Application No.: US12598881Application Date: 2008-05-02
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Publication No.: US08383341B2Publication Date: 2013-02-26
- Inventor: Nicolò Manaresi , Antonio Fittipaldi , Giuseppe Giorgini , Gianni Medoro
- Applicant: Nicolò Manaresi , Antonio Fittipaldi , Giuseppe Giorgini , Gianni Medoro
- Applicant Address: IT Bologna
- Assignee: Silicon Biosystems S.p.A.
- Current Assignee: Silicon Biosystems S.p.A.
- Current Assignee Address: IT Bologna
- Agency: Marshall, Gerstein & Borun LLP
- Priority: ITTO2007A0307 20070504
- International Application: PCT/IB2008/001083 WO 20080502
- International Announcement: WO2008/135837 WO 20081113
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; G01N33/53

Abstract:
Method for non-invasive prenatal diagnosis comprising the following steps: a. obtain a sample of an organic fluid having a high probability of containing foetal cells from a pregnant woman; b. enrich said sample of organic fluid in at least one population of cells comprising at least one type of foetal nucleated cells; c. isolate at least one cell from among said at least one type of foetal nucleated cells; d. perform a genetic analysis on said at least one cell isolated from among said at least one type of foetal nucleated cells in order to highlight at least one genetic characteristic of said at least one foetal nucleated cell suitable for permitting said diagnosis; wherein the step of isolating at least one cell from among said at least one type of foetal nucleated cells is performed by individually selecting single cells in a microfluidic device designed for said purpose.
Public/Granted literature
- US20100196897A1 Method and Device for Non-Invasive Prenatal Diagnosis Public/Granted day:2010-08-05
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