Invention Grant
- Patent Title: Modified RNA ligase for efficient 3′ modification of RNA
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Application No.: US12525176Application Date: 2008-01-30
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Publication No.: US08383370B2Publication Date: 2013-02-26
- Inventor: Thomas Tuschl , Janos Ludwig , Yi Pei , Carolina Lin
- Applicant: Thomas Tuschl , Janos Ludwig , Yi Pei , Carolina Lin
- Applicant Address: US NY New York
- Assignee: The Rockefeller University
- Current Assignee: The Rockefeller University
- Current Assignee Address: US NY New York
- Agency: Hoffmann & Baron, LLP
- International Application: PCT/US2008/001227 WO 20080130
- International Announcement: WO2008/094599 WO 20080807
- Main IPC: C12P19/34
- IPC: C12P19/34 ; C12N9/00 ; C12N1/20 ; C12N15/00 ; C07H21/04
Abstract:
The invention provides a novel truncated mutated T4 RNA ligase 2. In addition, methods are provided for ligating pre-adenlylated donor molecules to the 3′ hydroxyl group of RNA in the absence of ATP using the ligase.
Public/Granted literature
- US20110244523A1 Modified RNA Ligase for Efficient 3` Modification of RNA Public/Granted day:2011-10-06
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