Invention Grant
US08383583B2 Macrocyclic, pyridazinone-containing hepatitis C serine protease inhibitors
有权
大环哒嗪酮类丙型肝炎丝氨酸蛋白酶抑制剂
- Patent Title: Macrocyclic, pyridazinone-containing hepatitis C serine protease inhibitors
- Patent Title (中): 大环哒嗪酮类丙型肝炎丝氨酸蛋白酶抑制剂
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Application No.: US12257769Application Date: 2008-10-24
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Publication No.: US08383583B2Publication Date: 2013-02-26
- Inventor: Joel D. Moore , Yat Sun Or , Zhe Wang
- Applicant: Joel D. Moore , Yat Sun Or , Zhe Wang
- Applicant Address: US MA Watertown
- Assignee: Enanta Pharmaceuticals, Inc.
- Current Assignee: Enanta Pharmaceuticals, Inc.
- Current Assignee Address: US MA Watertown
- Agency: Elmore Patent Law Group, P.C.
- Agent Edgar W. Harlan; Carolyn S. Elmore, Esq.
- Main IPC: A61K38/00
- IPC: A61K38/00
Abstract:
The present invention relates to compounds of Formula I, II, or III, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising a compound of the present invention.
Public/Granted literature
- US20090123425A1 MACROCYCLIC, PYRIDAZINONE-CONTAINING HEPATITIS C SERINE PROTEASE INHIBITORS Public/Granted day:2009-05-14
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