Invention Grant
- Patent Title: Aryl isoxazole compounds with antitumoural activities
- Patent Title (中): 具有抗肿瘤活性的芳基异恶唑化合物
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Application No.: US13001652Application Date: 2009-06-30
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Publication No.: US08383616B2Publication Date: 2013-02-26
- Inventor: Giuseppe Giannini , Walter Cabri , Daniele Simoni , Riccardo Baruchello , Paolo Carminati , Claudio Pisano
- Applicant: Giuseppe Giannini , Walter Cabri , Daniele Simoni , Riccardo Baruchello , Claudio Pisano , Gabriella Singrossi , Silvia Carminati , Giuseppe Paolo Carminati
- Applicant Address: IT Rome
- Assignee: Sigma-Tau Industrie Farmaceutiche Riunite SpA
- Current Assignee: Sigma-Tau Industrie Farmaceutiche Riunite SpA
- Current Assignee Address: IT Rome
- Agency: Lucas & Mercanti, LLP
- Priority: EP08159692 20080704
- International Application: PCT/EP2009/058205 WO 20090630
- International Announcement: WO2010/000748 WO 20100107
- Main IPC: A61K31/397
- IPC: A61K31/397 ; A61K31/5377 ; A61K31/497 ; A61K31/4468 ; A61K31/422 ; A61K31/42 ; C07D413/12 ; C07D403/12 ; C07D401/12 ; C07D261/18
Abstract:
The present invention relates to formula I compounds having antitumoural activities through, as one possible biological target, the molecular chaperone heat shock protein 90 (Hsp90) inhibition. The invention includes the use of such compounds in medicine, in relation to cancer disease as well as other diseases where an inhibition of Hsp90 is responsive, and the pharmaceutical compositions containing such compounds.
Public/Granted literature
- US20110245221A1 ARYL ISOXAZOLE COMPOUNDS WITH ANTITUMOURAL ACTIVITIES Public/Granted day:2011-10-06
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