Invention Grant
US08383636B2 Acyclic amine inhibitors of 5-methytioadenosine phosphorylase and nucleosidase
有权
5-甲基硫代腺苷磷酸化酶和核苷酶的非环胺抑制剂
- Patent Title: Acyclic amine inhibitors of 5-methytioadenosine phosphorylase and nucleosidase
- Patent Title (中): 5-甲基硫代腺苷磷酸化酶和核苷酶的非环胺抑制剂
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Application No.: US12310597Application Date: 2007-09-07
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Publication No.: US08383636B2Publication Date: 2013-02-26
- Inventor: Keith Clinch , Gary Brian Evans , Richard Frohlich , Richard Hubert Furneaux , Peter Michael Kelly , Jennifer Mary Mason , Vern L. Schramm , Peter Charles Tyler , Shivall Ashwah Ashwin Gulab
- Applicant: Keith Clinch , Gary Brian Evans , Richard Frohlich , Richard Hubert Furneaux , Peter Michael Kelly , Jennifer Mary Mason , Vern L. Schramm , Peter Charles Tyler , Shivall Ashwah Ashwin Gulab
- Applicant Address: NZ Lower Hutt US NY Bronx
- Assignee: Industrial Research Limited,Albert Einstein College of Medicine of Yeshiva University
- Current Assignee: Industrial Research Limited,Albert Einstein College of Medicine of Yeshiva University
- Current Assignee Address: NZ Lower Hutt US NY Bronx
- Agency: Amster, Rothstein & Ebenstein LLP
- International Application: PCT/NZ2007/000260 WO 20070907
- International Announcement: WO2008/030118 WO 20080313
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K31/519 ; A61P35/00
Abstract:
The present invention relates to compounds of the general formula (I) which are inhibitors of 5′-methylthioadenosine phosphorylase or 5′-methylthioadenosine nucleosidase. The invention also relates to the use of these compounds in the treatment of diseases or conditions in which it is desirable to inhibit 5′-methylthioadenosine phosphorylase or 5′-methylthioadenosine nucleosidase including cancer, and to pharmaceutical compositions containing the compounds.
Public/Granted literature
- US20110046167A1 ACYCLIC AMINE INHIBITORS OF 5-METHYTIOADENOSINE PHOSPHORYLASE AND NUCLEOSIDASE Public/Granted day:2011-02-24
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