Invention Grant
US08383638B2 Aminobenzoquinazolinone M1 receptor positive allosteric modulators
有权
氨基苯喹唑啉酮M1受体阳性变构调节剂
- Patent Title: Aminobenzoquinazolinone M1 receptor positive allosteric modulators
- Patent Title (中): 氨基苯喹唑啉酮M1受体阳性变构调节剂
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Application No.: US13516941Application Date: 2010-12-13
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Publication No.: US08383638B2Publication Date: 2013-02-26
- Inventor: Scott D. Kuduk , Douglas C. Beshore , Christina Ng DiMarco , Thomas J. Greshock
- Applicant: Scott D. Kuduk , Douglas C. Beshore , Christina Ng DiMarco , Thomas J. Greshock
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme
- Current Assignee: Merck Sharp & Dohme
- Current Assignee Address: US NJ Rahway
- Agent Sylvia A. Ayler; Gerard M. Devlin
- International Application: PCT/US2010/060016 WO 20101213
- International Announcement: WO2011/084371 WO 20110714
- Main IPC: A61K31/517
- IPC: A61K31/517 ; A61K31/519 ; C07D239/88 ; C07D401/14 ; C07D405/04
Abstract:
The present invention is directed to aminobenzoquinazolinone compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.
Public/Granted literature
- US20120264761A1 Aminobenzoquinazolinone M1 Receptor Positive Allosteric Modulators Public/Granted day:2012-10-18
Information query
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