Invention Grant
- Patent Title: SIR2 regulation
- Patent Title (中): SIR2调节
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Application No.: US10560676Application Date: 2004-06-30
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Publication No.: US08383653B2Publication Date: 2013-02-26
- Inventor: Vern L. Schramm , Anthony A. Sauve
- Applicant: Vern L. Schramm , Anthony A. Sauve
- Applicant Address: US NY Bronx
- Assignee: Albert Einstein College of Medicine of Yeshiva University
- Current Assignee: Albert Einstein College of Medicine of Yeshiva University
- Current Assignee Address: US NY Bronx
- Agency: Amster, Rothstein & Ebenstein LLP
- International Application: PCT/US2004/020902 WO 20040630
- International Announcement: WO2005/016342 WO 20050224
- Main IPC: A61K31/445
- IPC: A61K31/445
Abstract:
Compounds are disclosed which inhibit SIR2 base exchange more than deacetylation, thus enhancing SIR2 deacetylation activity. Methods of using the compounds for enhancing SIR2 deacetylation activity and increasing longevity of an organism are also disclosed. Methods for screening for compounds that enhance SIR2 deacetylation activity and increase longevity of an organism are additionally disclosed.
Public/Granted literature
- US20110178102A1 SIR2 REGULATION Public/Granted day:2011-07-21
Information query
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