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US08383663B2 Bendamustine anionic-catioinic cyclopolysaccharide compositions 有权
苯达莫司汀阴离子型阴离子多环多糖组合物

Bendamustine anionic-catioinic cyclopolysaccharide compositions
Abstract:
The present invention is directed to pharmaceutical compositions including: (a) bendamustine, (b) a first charged cyclopolysaccharide, and (c) a stabilizing agent which is a second charged cyclopolysaccharide having a charge opposite to that of the first charged cyclopolysaccharide. The composition provides unexpectedly desirable stability in reactive environments such as plasma, coupled with unexpectedly desirable anticancer activity. The compositions are suitable for injection or infusion into patients in need for treatment with bendamustine.
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