Invention Grant
US08383773B2 Protein product and method for reducing biomass-biomass interactions
有权
用于减少生物量 - 生物相互作用的蛋白质产物和方法
- Patent Title: Protein product and method for reducing biomass-biomass interactions
- Patent Title (中): 用于减少生物量 - 生物相互作用的蛋白质产物和方法
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Application No.: US12777211Application Date: 2010-05-10
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Publication No.: US08383773B2Publication Date: 2013-02-26
- Inventor: Richard L. Gehant
- Applicant: Richard L. Gehant
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Morrison & Foerster LLP
- Main IPC: C07K1/00
- IPC: C07K1/00

Abstract:
The invention includes a process for extracting a target protein from Escherichia coli (E. coli) cells that includes lowering the pH of a whole E. coli cell solution to form an acidic solution, disrupting the cells to release the protein into the acidic solution, and separating the cellular debris from the released protein to obtain a protein product enriched in the heterologous target protein. The invention also includes addition of a solubility enhancer.
Public/Granted literature
- US20110124845A1 PROCESS FOR PROTEIN EXTRACTION Public/Granted day:2011-05-26
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