Invention Grant
- Patent Title: Nucleic acids encoding antibodies that bind factor D
- Patent Title (中): 编码结合因子D的抗体的核酸
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Application No.: US13540275Application Date: 2012-07-02
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Publication No.: US08383802B2Publication Date: 2013-02-26
- Inventor: Michael S. C. Fung , William N. C. Sun , Cecily R. Y. Sun
- Applicant: Michael S. C. Fung , William N. C. Sun , Cecily R. Y. Sun
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Jones Day
- Main IPC: C12N15/13
- IPC: C12N15/13 ; C12N15/00 ; C12N5/10
Abstract:
The invention relates to factor D inhibitors, which bind to factor D and block the functional activity of factor D in complement activation. The inhibitors include antibody molecules, as well as homologues, analogues and modified or derived forms thereof, including immunoglobulin fragments like Fab, F(ab′)2 and Fv, small molecules, including peptides, oligonucleotides, peptidomimetics and organic compounds. A monoclonal antibody which bound to factor D and blocked its ability to activate complement was generated and designated 166-32. The hybridoma producing this antibody was deposited at the American Type Culture Collection, 10801 University Blvd., Manassas, Va. 20110-2209, under Accession Number HB-12476.
Public/Granted literature
- US20120322975A1 NUCLEIC ACIDS ENCODING ANTIBODIES THAT BIND FACTOR D Public/Granted day:2012-12-20
Information query
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