Invention Grant
US08383806B2 Method of reversing carboplatin resistance by inhibition of HGFIN
有权
通过抑制HGFIN逆转卡铂抗性的方法
- Patent Title: Method of reversing carboplatin resistance by inhibition of HGFIN
- Patent Title (中): 通过抑制HGFIN逆转卡铂抗性的方法
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Application No.: US13085612Application Date: 2011-04-13
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Publication No.: US08383806B2Publication Date: 2013-02-26
- Inventor: Pranela Rameshwar
- Applicant: Pranela Rameshwar
- Applicant Address: US NJ Somerset
- Assignee: University of Medicine and Dentistry of New Jersey
- Current Assignee: University of Medicine and Dentistry of New Jersey
- Current Assignee Address: US NJ Somerset
- Agency: Licata & Tyrrell P.C.
- Main IPC: C07H21/02
- IPC: C07H21/02 ; A61K39/00
Abstract:
The present invention discloses the cloning of a new cDNA, HGFIN, from stimulated bone marrow stromal cells that was retrieved with a probe specific for the neurokinin-1 (NK-1) receptor. The novel gene, HGFIN, encodes a protein receptor that is involved in the regulation of hematopoietic proliferation and differentiation. HGFIN is implicated in the treatment of hyperproliferative disorders, particularly bone and breast cancer, because it acts to suppress the proliferating cells.
Public/Granted literature
- US20110237519A1 Hematopoietic Growth Factor Inducible Neurokinin-1 Gene and Uses Thereof Public/Granted day:2011-09-29
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