A computer-based assessment driven cognition system includes, in embodiments, a generator configured to present questions, where each question presented is associated with a stacking weight and has at least one correct response, and a question property evaluator configured to, for each question presented, determine a likelihood of randomly selecting the at least one correct response. The system also includes a question response receiver configured to receive at least one response to each question presented. Additionally, the system includes a question response evaluator configured to determine, for each question presented, when the at least one response is the at least one associated correct response, a likelihood that the at least one response is a false positive. The question response evaluator is further configured to adjust the stacking weight of each question presented depending at least upon the likelihood that the at least one response to the question is a false positive.