Systems and methods are provided for detecting an anomaly in a hidden portion of a first layer of a multi-layer structure. A monitoring element is provided on at least one exposed end of a fastener that extends through the multi-layer structure, and another monitoring element on an exposed portion of the first layer. With at least one of the monitoring elements, an inspection signal is introduced into the multi-layer structure including the hidden portion of the first layer. The inspection signal is then sensed with at least another one of the monitoring elements following propagation of the inspection signal through at least a portion of the multi-layer structure including the hidden portion of the first layer. Finally, an anomaly may be detected in the hidden portion of the first layer based upon the inspection signal that has been sensed.