Systems and methods may be provided for a prescription safety network program. The systems and methods may include receiving an eligibility verification request for a prescribed drug or product, where the eligibility verification request may include a pharmacy identifier, a patient identifier, and physician identifier; determining, based upon the received pharmacy identifier, that a pharmacy associated with the pharmacy identifier has enrolled in the prescription safety network program for filling the prescribed drug or product; determining, based upon the received patient identifier, that a patient associated with the patient identifier has enrolled in the prescription safety network program for utilizing the prescribed drug or product; and determining, based upon the received physician identifier, that a physician associated with the physician identifier has enrolled in the prescription safety network program for prescribing the prescribed drug or product; and generating an approval authorization by the validation engine in response to the eligibility verification request.