There is described a method and system for producing notes of securities, in particular banknotes, wherein individual printed sheets or successive printed portions of a continuous web are cut into individual notes on a sheet-fed or web-fed processing system, and wherein these individual notes are subsequently processed by a single-note processing system comprising a plurality of single-note processing stations. Individual notes corresponding to independent production cycles or dependent production cycles are produced on the sheet-fed or web-fed processing system, each production cycle being processed on a separate one of the single-note processing stations. Each production cycle is subdivided into a sequence of distinct production sub-cycles corresponding to successive subsets of individual notes (150) that are to be processed on the single-note processing stations, the subsets of individual notes being produced on the sheet-fed or web-fed processing system (300) according to a time-wise interleaved sequence of production sub-cycles corresponding to distinct production cycles.