Dental implant with biomimetic osteointegrative interface has a substrate of biocompatible material with a first layer thereon, having a first concentration of oxide of the biocompatible material, enriched with a second concentration of phosphorus and with a third concentration of calcium. The ratio between the concentration of calcium and the concentration of phosphorus is greater than two and the biomimetic osteointegrative interface further comprising a second layer having a first surface in contact with the first layer, and a second surface, the second layer having a fourth concentration of oxide enriched with a fifth concentration of calcium and a sixth concentration of phosphorus, the fourth concentration being less than the fifth and sixth concentrations and the ratio between the fifth concentration of calcium and the sixth concentration of phosphorus being no less than three.