Invention Grant
- Patent Title: Apolipoprotein fingerprinting technique and methods related thereto
- Patent Title (中): 载脂蛋白指纹技术及其相关方法
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Application No.: US12236417Application Date: 2008-09-23
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Publication No.: US08389222B2Publication Date: 2013-03-05
- Inventor: Emelita De Guzman Breyer , Mary K. Robinson
- Applicant: Emelita De Guzman Breyer , Mary K. Robinson
- Applicant Address: US GA Tucker US GA Tucker
- Assignee: Emelita D. Breyer,Sean M. Breyer
- Current Assignee: Emelita D. Breyer,Sean M. Breyer
- Current Assignee Address: US GA Tucker US GA Tucker
- Main IPC: G01N33/53
- IPC: G01N33/53

Abstract:
A method for determining the concentration and modifications of apolipoprotein in biological samples including plasma, serum, and lipoprotein fractions, by obtaining a sample from a patient, adding a specific volume of an internal standard to the sample, applying the sample to a surface-enhanced, Protein G-coated, antibody-bound chip and removing unbound sample components, analyzing the sample by mass spectrometry, determining the concentration of the apolipoprotein using values of internal standards, and evaluating the concentration of the apolipoprotein, its isoforms, amino acid substitutions and modifications for use as a tool for diagnosing cancer, diabetes, stroke, stress, Alzheimer's disease, inflammation, neurological disease and cardiovascular diseases.
Public/Granted literature
- US20090155812A1 APOLIPOPROTEIN FINGERPRINTING TECHNIQUE AND METHODS RELATED THERETO Public/Granted day:2009-06-18
Information query
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