Invention Grant
US08389227B2 Method for diagnosing cancers expressing the HER2 receptor or its truncated variants
有权
用于诊断表达HER2受体或其截短变体的癌症的方法
- Patent Title: Method for diagnosing cancers expressing the HER2 receptor or its truncated variants
- Patent Title (中): 用于诊断表达HER2受体或其截短变体的癌症的方法
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Application No.: US12479035Application Date: 2009-06-05
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Publication No.: US08389227B2Publication Date: 2013-03-05
- Inventor: Joaquin Arribas Lopez , Kim Pedersen , Pier-Davide Angellini , Josep Liuis Parra Palau , Sirle Laos , Jose Baselga Torres
- Applicant: Joaquin Arribas Lopez , Kim Pedersen , Pier-Davide Angellini , Josep Liuis Parra Palau , Sirle Laos , Jose Baselga Torres
- Applicant Address: ES Barcelona ES Barcelona ES Barcelona
- Assignee: Fundacio Privada Institut de Recerca Hospital Universitari Vall Hebron,Fundacio Privada Institucio Catalana de Recera I Estudis Avancats,Fundacio Privada Institut d'Investigacio Oncologica de Vall Hebron
- Current Assignee: Fundacio Privada Institut de Recerca Hospital Universitari Vall Hebron,Fundacio Privada Institucio Catalana de Recera I Estudis Avancats,Fundacio Privada Institut d'Investigacio Oncologica de Vall Hebron
- Current Assignee Address: ES Barcelona ES Barcelona ES Barcelona
- Agency: McAndrews, Held & Malloy Ltd.
- Main IPC: C12P21/08
- IPC: C12P21/08 ; C07K16/30 ; C07K16/28 ; G01N33/574 ; G01N33/573 ; G01N33/567 ; G01N33/50 ; C07K17/16
Abstract:
The present invention relates to a method of diagnosis and therapy of cancers expressing the HER2 receptor.The invention provides antibodies or fragments thereof that recognizes an epitope of a HER2 receptor truncated form, said epitope being defined by a sequence included in SEQ ID NO: 2.The invention also provides a method of cancer diagnosis, which comprises the detection of the presence of the HER2 receptor truncated form consisting of the amino acid sequence SEQ ID NO: 1 in a patient sample.
Public/Granted literature
- US20090311262A1 Method for Diagnosing Cancers Expressing the HER2 Receptor or its Truncated Variants Public/Granted day:2009-12-17
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