Invention Grant
US08389505B2 Adamantane derivatives of AZA-crown ethers and their use in treatment of tumor
有权
AZA冠醚的金刚烷衍生物及其在肿瘤治疗中的应用
- Patent Title: Adamantane derivatives of AZA-crown ethers and their use in treatment of tumor
- Patent Title (中): AZA冠醚的金刚烷衍生物及其在肿瘤治疗中的应用
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Application No.: US13107492Application Date: 2011-05-13
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Publication No.: US08389505B2Publication Date: 2013-03-05
- Inventor: Marijeta Kralj , Kata Majerski , Tatjana Sumanovac Ramljak , Marko Marjanovic
- Applicant: Marijeta Kralj , Kata Majerski , Tatjana Sumanovac Ramljak , Marko Marjanovic
- Applicant Address: HR
- Assignee: Rudjer Boskovic Institute
- Current Assignee: Rudjer Boskovic Institute
- Current Assignee Address: HR
- Agency: St. Onge Steward Johnston & Reens LLC
- Priority: HRP20090355A 20090619
- Main IPC: A61K31/33
- IPC: A61K31/33 ; C07D273/08

Abstract:
The invention relates to adamantane diaza-crown ether derivatives and the use of mono and diaza-crown ether adamantine derivatives in treatment, especially in tumor treatment. Adamantane aza-crown ethers were obtained by reaction of the corresponding adamantane derived tosylates or adamantane acid chlorides with mono- and diaza-18-crown-6. The prepared compounds showed moderate (monoaza-18-crown-6) to strong (diaza-18-crown-6) antiproliferative and cytotoxic activity on several tumor cell lines, revealing their potential for inhibiting the growth of other tumor cells.
Public/Granted literature
- US20110257254A1 Adamantane Derivatives Of Aza-Crown Ethers And Their Use In Treatment Of Tumor Public/Granted day:2011-10-20
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