Invention Grant
US08389709B2 Compositions and methods for treating tumors, fibrosis, and pulmonary alveolar proteinosis
有权
用于治疗肿瘤，纤维化和肺泡蛋白沉积症的组合物和方法
- Patent Title: Compositions and methods for treating tumors, fibrosis, and pulmonary alveolar proteinosis
- Patent Title (中): 用于治疗肿瘤，纤维化和肺泡蛋白沉积症的组合物和方法
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Application No.: US12669035Application Date: 2008-07-15
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Publication No.: US08389709B2Publication Date: 2013-03-05
- Inventor: Gera Neufeld
- Applicant: Gera Neufeld
- Applicant Address: IL Haifa
- Assignee: Technion Research & Development Foundation Ltd.
- Current Assignee: Technion Research & Development Foundation Ltd.
- Current Assignee Address: IL Haifa
- Agency: Morrison & Foerster LLP
- Priority: IL184627 20070715
- International Application: PCT/IL2008/000985 WO 20080715
- International Announcement: WO2009/010974 WO 20090122
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C07H21/02 ; C12N15/85 ; C12N15/63 ; A61K48/00
Abstract:
The present disclosure provides pharmaceutical compositions and methods useful for modulating angiogenesis and for inhibiting metastasis, tumors, pulmonary alveolar proteinosis, and fibrosis in a mammalian tissue. Pharmaceutical compositions and methods include inhibitors of LOXL2 expression and activity, such as shRNA targeting LOXL2.
Public/Granted literature
- US20100317721A1 Compositions and Methods for Treating Tumors, Fibrosis, and Pulmonary Alveolar Proteinosis Public/Granted day:2010-12-16
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