Invention Grant
US08389714B2 Process for the preparation of 17-0-vinyl-triflates as intermediates
有权
制备17-0-乙烯基 - 三氟甲磺酸酯作为中间体的方法
- Patent Title: Process for the preparation of 17-0-vinyl-triflates as intermediates
- Patent Title (中): 制备17-0-乙烯基 - 三氟甲磺酸酯作为中间体的方法
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Application No.: US13137193Application Date: 2011-07-27
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Publication No.: US08389714B2Publication Date: 2013-03-05
- Inventor: Paul S Bury
- Applicant: Paul S Bury
- Applicant Address: GB London
- Assignee: BTG International Limited
- Current Assignee: BTG International Limited
- Current Assignee Address: GB London
- Agency: Nixon & Vanderhye
- Priority: GB0418900.7 20040824; GB0418901.5 20040824
- Main IPC: C07J43/00
- IPC: C07J43/00
Abstract:
A compound of formula (I) or a pharmaceutically-acceptable salt thereof, may be made by a process including a triflating step by which a ketone of formula (II) is converted into a triflate of formula (III) in the presence of a base comprising a tertiary or heterocyclic amine such that the pKa of the conjugate acid at 25° C. is within the range 5.21 to 12.
Public/Granted literature
- US20110288288A1 Process for the preparation of 17-0-vinyl- triflates as intermediates Public/Granted day:2011-11-24
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