A method and system for using call drop and re-origination data to trigger handoff of wireless communication devices. Handoff trigger data is established in response to detecting that at least one mobile station experienced a call drop and then quickly re-originated on a sector that was not included in the mobile station's active set at the time of the call drop. The handoff trigger data correlates a location where the call drop occurred with the sector on which re-origination occurred. When another mobile station is thereafter engaged in a call at or near that location and does not have the sector in its active set, a serving radio access network may direct the mobile station to handoff to the sector, in an effort to prevent a call drop.