A method for determining a time to aortic valve closure comprises receiving data corresponding to an imaged region of a left ventricle of a heart. A plurality of points within the data is identified. A peak negative strain is determined for each of the points and the peak negative strain comprises a maximum contraction value and a time from onset to maximum contraction value. A weight value for each of the points is determined based on the peak negative strain. A time to aortic valve closure is determined based on the weight value and the time from onset to maximum contraction value for each of the points.