A nickel-base alloy having favorable toughness and thermal fatigue resistance comprises, in weight percentages based on total alloy weight: 9 to 12 chromium; 25 to 35 iron; 1 to 3 molybdenum; 3.0 to 5.5 niobium; 0.2 to 2.0 aluminum; 0.3 to 3.0 titanium; less than 0.10 carbon; no more than 0.01 boron; nickel; and incidental impurities. Also disclosed are die casting dies, other tooling, and other articles of manufacture made from or comprising the nickel-base alloy.