Invention Grant
US08394811B2 Hydrazide compounds as thyroid hormone receptor modulators and uses thereof
有权
酰肼化合物作为甲状腺激素受体调节剂及其用途
- Patent Title: Hydrazide compounds as thyroid hormone receptor modulators and uses thereof
- Patent Title (中): 酰肼化合物作为甲状腺激素受体调节剂及其用途
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Application No.: US12450922Application Date: 2008-04-18
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Publication No.: US08394811B2Publication Date: 2013-03-12
- Inventor: Herbert H. Samuels , Ruben Abagyan , Matthieu Schapira , Maxim Totrov , Bruce M. Raaka , Stephen R. Wilson , Li Fan , Zhiguo Zhou
- Applicant: Herbert H. Samuels , Ruben Abagyan , Matthieu Schapira , Maxim Totrov , Bruce M. Raaka , Stephen R. Wilson , Li Fan , Zhiguo Zhou
- Applicant Address: US CA La Jolla US NY New York
- Assignee: Molsoft LLC,New York University School of Medicine
- Current Assignee: Molsoft LLC,New York University School of Medicine
- Current Assignee Address: US CA La Jolla US NY New York
- Agency: Klauber & Jackson LLC
- International Application: PCT/US2008/005031 WO 20080418
- International Announcement: WO2008/130637 WO 20081030
- Main IPC: A61K31/438
- IPC: A61K31/438 ; A61K31/4418 ; A61P5/16 ; C07D211/70 ; C07D471/10
Abstract:
A method of identification of compounds that modulate thyroid hormone activity, and the use of such compounds and compositions thereof for such purposes are disclosed. The compounds may be selected from the group consisting of: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of conditions that are causally related to aberrant thyroid hormone activity, such as hyperthyroidism and thyrotoxicosis.
Public/Granted literature
- US20100286182A1 HYDRAZIDE COMPOUNDS AS THYROID HORMONE RECEPTOR MODULATORS AND USES THEREOF Public/Granted day:2010-11-11
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