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Invention Grant
US08394824B2 Quinuclidine compounds having quaternary ammonium group, its preparation method and use as blocking agents of acetylcholine 有权
具有季铵基的奎宁环化合物，其制备方法和用作乙酰胆碱的封闭剂

  • Patent Title: Quinuclidine compounds having quaternary ammonium group, its preparation method and use as blocking agents of acetylcholine
  • Patent Title (中): 具有季铵基的奎宁环化合物，其制备方法和用作乙酰胆碱的封闭剂
  • Application No.: US13239892
    Application Date: 2011-09-22
  • Publication No.: US08394824B2
    Publication Date: 2013-03-12
  • Inventor: Shuqiang Zhao
  • Applicant: Shuqiang Zhao
  • Applicant Address: CN Beijing
  • Assignee: Shuqiang Zhao
  • Current Assignee: Shuqiang Zhao
  • Current Assignee Address: CN Beijing
  • Agency: Turocy & Watson, LLP
  • Main IPC: A61K31/439
  • IPC: A61K31/439 ;  A61P1/00 ;  A61P11/00
Quinuclidine compounds having quaternary ammonium group, its preparation method and use as blocking agents of acetylcholine
Abstract:
The invention relates to the quinuclidine compounds of formula I having quaternary ammonium group, its preparation, and the pharmaceutical composition comprising an effective amount of the compound of formula I. The compound and the composition are used to prevent and treat the diseases by blocking acetylcholine receptor. Wherein: R1 is selected from C1-12 saturated straight-chain alkyl and cycloalkyl; R2 is selected from C1-12 saturated straight-chain alkyl or straight-chain alkyl; and X is selected from halogen ion, organic and inorganic acid radical.
Abstract(Chinese):

本发明涉及具有季铵基团的式I的奎宁环化合物及其制备方法和包含有效量的式I化合物的药物组合物。该化合物和组合物用于通过阻断乙酰胆碱受体来预防和治疗疾病 。 其中R1选自C1-12饱和直链烷基和环烷基; R2选自C1-12饱和直链烷基或直链烷基; X选自卤素离子，有机和无机酸基。

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