Invention Grant
- Patent Title: Indoles and their therapeutic use
- Patent Title (中): 吲哚及其治疗用途
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Application No.: US12746104Application Date: 2008-12-12
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Publication No.: US08394836B2Publication Date: 2013-03-12
- Inventor: George Hynd , John Gary Montana , Harry Finch , Rosa Arienzo , Barbara Avitabile-Woo , Mathias Domostoj
- Applicant: George Hynd , John Gary Montana , Harry Finch , Rosa Arienzo , Barbara Avitabile-Woo , Mathias Domostoj
- Applicant Address: GB Berkshire
- Assignee: Pulmagen Therapeutics (Asthma) Limited
- Current Assignee: Pulmagen Therapeutics (Asthma) Limited
- Current Assignee Address: GB Berkshire
- Agency: Saliwanchik, Lloyd & Eisenschenk
- Priority: GB0724429.6 20071214; GB0806083.2 20080403; GB0814910.6 20080814
- International Application: PCT/GB2008/004107 WO 20081212
- International Announcement: WO2009/077728 WO 20090625
- Main IPC: A61K31/4439
- IPC: A61K31/4439 ; C07D409/12 ; C07D401/12

Abstract:
Compound of formula (I) are ligands of the CRTH2 receptor, useful inter alia for treatment of inflammatory conditions. Wherein X is —SO2— or *—SO2NR3— wherein the bond marked with an asterisk is attached to Ar1; R1 is hydrogen, fluoro, chloro, CN or CF3; R2 is hydrogen, fluoro or chloro; R3 is hydrogen, C1C8alkyl or C3-C7cycloalkyl; Ar1 is phenyl or a 5- or 6-membered heteroaryl group selected from furanyl, thienyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl, pyridinyl, pyridazinyl, pyrimidinyl and pyrazinyl, wherein the phenyl or heteroaryl groups are optionally substituted by one or more substituents independently selected from fluoro, chloro, CN, C3-C7cycloalkyl, —O(C1-C4alkyl) or C1C6alkyl, the latter two groups being optionally substituted by one or more fluoro atoms; and Ar2 is phenyl or 5- or 6-membered heteroaryl group selected from pyrrolyl, furanyl, thienyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl, pyridinyl, pyridazinyl, pyrimidinyl and pyrazinyl, wherein the phenyl or heteroaryl groups are optionally substituted by one or more substituents independently selected from fluoro, chloro, CN, C3-C3-C7cycloalkyl, —O(C1-C4alkyl) or C1C6alkyl, the latter two groups being optionally substituted by one or more fluoro atoms.
Public/Granted literature
- US20110071175A1 Indoles and Their Therapeutic Use Public/Granted day:2011-03-24
Information query
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