Invention Grant
US08394837B2 2,3,4,6-substituted pyridyl derivative compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease
有权
用作治疗阿尔茨海默氏病的β-分泌酶抑制剂的2,3,4,6-取代的吡啶衍生物化合物
- Patent Title: 2,3,4,6-substituted pyridyl derivative compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease
- Patent Title (中): 用作治疗阿尔茨海默氏病的β-分泌酶抑制剂的2,3,4,6-取代的吡啶衍生物化合物
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Application No.: US11791204Application Date: 2005-11-18
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Publication No.: US08394837B2Publication Date: 2013-03-12
- Inventor: Philippe G. Nantermet , Hemaka A. Rajapakse , Harold G. Selnick , James C. Barrow , Shaun R. Stauffer , Joseph P. Vacca , Keith P. Moore , Shawn J. Stachel , Mattahew G. Stanton
- Applicant: Philippe G. Nantermet , Hemaka A. Rajapakse , Harold G. Selnick , James C. Barrow , Shaun R. Stauffer , Joseph P. Vacca , Keith P. Moore , Shawn J. Stachel , Mattahew G. Stanton
- Applicant Address: US NJ Rahway
- Assignee: Merck, Sharp & Dohme, Corp.
- Current Assignee: Merck, Sharp & Dohme, Corp.
- Current Assignee Address: US NJ Rahway
- Agent Keith D. MacMillan; Gerard M. Devlin
- International Application: PCT/US2005/042087 WO 20051118
- International Announcement: WO2006/057945 WO 20060601
- Main IPC: A61K31/4439
- IPC: A61K31/4439 ; C07D413/04
Abstract:
The present invention is directed to 2,3,4,6-substituted pyridyl derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
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