Invention Grant
- Patent Title: Fc variants with altered binding to FcRn
- Patent Title (中): Fc变体与FcRn结合改变
-
Application No.: US13326776Application Date: 2011-12-15
-
Publication No.: US08394925B2Publication Date: 2013-03-12
- Inventor: Aaron Keith Chamberlain , Bassil I. Dahiyat , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar
- Applicant: Aaron Keith Chamberlain , Bassil I. Dahiyat , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar
- Applicant Address: US CA Monrovia
- Assignee: Xencor, Inc.
- Current Assignee: Xencor, Inc.
- Current Assignee Address: US CA Monrovia
- Agency: Morgan, Lewis & Bockius LLP
- Agent Robin M. Silva; Gargi Talukder
- Main IPC: C07K1/00
- IPC: C07K1/00 ; C07K16/00 ; C12P21/08 ; A61K39/395 ; A61K39/40 ; A61K39/00
Abstract:
The present application relates to a variant Fc region comprising the double mutation 428L/434S that increases serum half-life and the numbering is according to the EU index.
Public/Granted literature
- US20120088905A1 Fc VARIANTS WITH ALTERED BINDING TO FcRn Public/Granted day:2012-04-12
Information query
