Invention Grant
- Patent Title: Positionally modified siRNA constructs
- Patent Title (中): 位置修饰的siRNA构建体
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Application No.: US11569939Application Date: 2004-03-03
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Publication No.: US08394947B2Publication Date: 2013-03-12
- Inventor: Balkrishen Bhat , Eric E. Swayze , Thazha P. Prakash , Charles Allerson , Prasad Dande , Richard H. Griffey
- Applicant: Balkrishen Bhat , Eric E. Swayze , Thazha P. Prakash , Charles Allerson , Prasad Dande , Richard H. Griffey
- Applicant Address: US CA Carlsbad
- Assignee: Isis Pharmaceuticals, Inc.
- Current Assignee: Isis Pharmaceuticals, Inc.
- Current Assignee Address: US CA Carlsbad
- Agency: Woodcock Washburn LLP
- International Application: PCT/US2004/017485 WO 20040303
- International Announcement: WO2005/120230 WO 20051222
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04 ; A61K31/70 ; C12Q1/68
Abstract:
The present invention provides oligomeric compounds having sufficient complementarity to hybridize to a nucleic acid target and methods for their use in modulating gene expression. In one embodiment the oligomeric compounds comprise double stranded constructs wherein one of the strands capable of hybridizing to a nucleic acid target, and has a plurality of modified ribofuranosyl nucleosides at defined locations. The presence of modifications at such defined positions greatly enhances the properties of the corresponding compositions.
Public/Granted literature
- US20080146788A1 Positionally Modified Sirna Constructs Public/Granted day:2008-06-19
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