Invention Grant
- Patent Title: 2,4 (4,6) pyrimidine derivatives
- Patent Title (中): 2,4（4,6）嘧啶衍生物
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Application No.: US13277651Application Date: 2011-10-20
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Publication No.: US08394955B2Publication Date: 2013-03-12
- Inventor: Eddy Jean Edgard Freyne , Marc Willems , Werner Constant Johan Embrechts , Kristof Van Emelen , Sven Franciscus Anna Van Brandt , Frederik Jan Rita Rombouts
- Applicant: Eddy Jean Edgard Freyne , Marc Willems , Werner Constant Johan Embrechts , Kristof Van Emelen , Sven Franciscus Anna Van Brandt , Frederik Jan Rita Rombouts
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica N.V.
- Current Assignee: Janssen Pharmaceutica N.V.
- Current Assignee Address: BE Beerse
- Priority: EP04106384 20041208
- Main IPC: C07D239/02
- IPC: C07D239/02
Abstract:
The present invention is drawn to intermediates relating to 2,4 (4,6) pyrimidine derived macrocycles, pharmaceutical compositions thereof, and methods of making said compounds. The compounds disclosed herein are inhibitors of EGF receptor tyrosine kinases and are useful for treating cell proliferative disorders, including atherosclerosis, restenosis, and cancer.
Public/Granted literature
- US20120065395A1 2,4 (4,6) PYRIMIDINE DERIVATIVES Public/Granted day:2012-03-15
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