Invention Grant
- Patent Title: Process for the preparation of pharmaceutical intermediates
- Patent Title (中): 制备药物中间体的方法
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Application No.: US12742484Application Date: 2008-11-27
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Publication No.: US08394993B2Publication Date: 2013-03-12
- Inventor: Tibor Mezei , Gyula Lukács , Enikó Molnár , József Barkóczy , Balázs Volk , Márta Porcs-Makkay , János Szulágyi , Mária Vajjon
- Applicant: Tibor Mezei , Gyula Lukács , Enikó Molnár , József Barkóczy , Balázs Volk , Márta Porcs-Makkay , János Szulágyi , Mária Vajjon
- Applicant Address: HU Budapest
- Assignee: Egis Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag
- Current Assignee: Egis Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag
- Current Assignee Address: HU Budapest
- Agent Jonathan Myers; Andrew Wilford
- Priority: HU0700756 20071127
- International Application: PCT/HU2008/000138 WO 20081127
- International Announcement: WO2009/068923 WO 20090604
- Main IPC: C07D495/04
- IPC: C07D495/04 ; C07C45/45 ; C07C45/65

Abstract:
The invention relates to a process for the preparation of cyclopropyl benzyl ketone compounds of formula (II) wherein R1 represents fluorine or chlorine atom or C1-4 alkoxy group, by the reaction of a Grignard reagent, obtained from the reaction of compound of formula (V), wherein X represents chlorine or fluorine atom, with the compound of formula (IV), wherein R2 represents C1-4 alkyl group, having a straight or branched chain. The process can be applied preferably on industrial scale. Compound of formula (II), wherein R represents a fluorine atom in position 2 is an intermediate of the preparation process of prasugrel, which is a platelet inhibitor used in the therapy.
Public/Granted literature
- US20100274020A1 PROCESS FOR THE PREPARATION OF PHARMACEUTICAL INTERMEDIATES Public/Granted day:2010-10-28
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