A semiconductor memory device is operated by reading data stored in LSB and MSB pages of a first word line in response to a read command and storing the read data in first and second latches of a page buffer, outputting the data stored in the first latch externally and transferring the data, stored in the second latch, to a third latch of the page buffer, resetting the first and second latches, reading data stored in LSB and MSB pages of a second word line, and storing the read data in the first and second latches, and sequentially outputting the data stored in the first latch and the data stored in the third latch, resetting the third latch, and then transferring the data stored in the second latch to the third latch.