Invention Grant
- Patent Title: IL-1 binding proteins
- Patent Title (中): IL-1结合蛋白
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Application No.: US12905499Application Date: 2010-10-15
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Publication No.: US08398966B2Publication Date: 2013-03-19
- Inventor: Chengbin Wu , Chung-ming Hsieh , Renee Miller , Dominic J. Ambrosi
- Applicant: Chengbin Wu , Chung-ming Hsieh , Renee Miller , Dominic J. Ambrosi
- Applicant Address: US IL North Chicago
- Assignee: AbbVie Inc.
- Current Assignee: AbbVie Inc.
- Current Assignee Address: US IL North Chicago
- Agency: Lathrop & Gage LLP
- Agent James H. Velema, Esq.
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/24

Abstract:
The present invention describes IL-1β binding proteins, including chimeric, CDR-grafted, and humanized antibodies that bind IL-1β. Binding proteins of the invention have high affinity for IL-1β and neutralize IL-1β activity. A binding protein of the invention can be a full-length antibody or an IL-1β-binding portion thereof. Methods of making and methods of using the binding proteins of the invention are also described. The IL-1β binding proteins of the invention are useful for detecting IL-1β and for inhibiting IL-1β activity, including in a human subject suffering from a disease or disorder in which IL-1β activity is detrimental.
Public/Granted literature
- US20110142761A1 IL-1 BINDING PROTEINS Public/Granted day:2011-06-16
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