Invention Grant
US08399248B2 Methods of using MIR34 as a biomarker for TP53 functional status
有权
使用MIR34作为TP53功能状态的生物标志物的方法
- Patent Title: Methods of using MIR34 as a biomarker for TP53 functional status
- Patent Title (中): 使用MIR34作为TP53功能状态的生物标志物的方法
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Application No.: US12598563Application Date: 2008-05-05
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Publication No.: US08399248B2Publication Date: 2013-03-19
- Inventor: Michele A. Cleary , Aimee L. Jackson , Peter S. Linsley , Julja Burchard , Lee P. Lim , Jill F. Magnus , Lin He , Xingyue He , Scott W. Lowe , Gregory J. Hannon
- Applicant: Michele A. Cleary , Aimee L. Jackson , Peter S. Linsley , Julja Burchard , Lee P. Lim , Jill F. Magnus , Lin He , Xingyue He , Scott W. Lowe , Gregory J. Hannon
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agency: Christensen O'Connor Johnson Kindness PLLC
- International Application: PCT/US2008/062681 WO 20080505
- International Announcement: WO2008/137862 WO 20081113
- Main IPC: C12N15/85
- IPC: C12N15/85 ; C07H21/04 ; C07H21/02
Abstract:
In one aspect, the invention generally relates to use of miR-34 as a biomarker to estimate TP53 function in a cell. In another aspect, the invention generally relates to multiple uses of miR-34 and siRNAs functionally and structurally related to miR-34 for the treatment of cancer.
Public/Granted literature
- US20110105583A1 METHODS OF USING MIR34 AS A BIOMARKER FOR TP53 FUNCTIONAL STATUS Public/Granted day:2011-05-05
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