Invention Grant
- Patent Title: Chemical linkers and conjugates thereof
- Patent Title (中): 化学接头及其共轭物
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Application No.: US12610952Application Date: 2009-11-02
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Publication No.: US08399403B2Publication Date: 2013-03-19
- Inventor: Sharon E. Boyd , Liang Chen , Sanjeev Gangwar , Vincent Guerlavais , Kilian Horgan , Zhi-Hong Li , Bilal Sufi
- Applicant: Sharon E. Boyd , Liang Chen , Sanjeev Gangwar , Vincent Guerlavais , Kilian Horgan , Zhi-Hong Li , Bilal Sufi
- Applicant Address: US NJ Princeton
- Assignee: Medarex, Inc.
- Current Assignee: Medarex, Inc.
- Current Assignee Address: US NJ Princeton
- Agency: Nelson Mullins Riley & Scarborough LLP
- Agent Jane E. Remillard, Esq.; Pankaj N. Desai
- Main IPC: A61K38/00
- IPC: A61K38/00
Abstract:
The present disclosure provides drug-ligand conjugates that are potent cytotoxins, wherein the drug is linked to the ligand through either a peptidyl, hydrazine, or disulfide linker. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.
Public/Granted literature
- US20100092496A1 CHEMICAL LINKERS AND CONJUGATES THEREOF Public/Granted day:2010-04-15
Information query
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