Invention Grant
- Patent Title: Azacytidine analogues and uses thereof
- Patent Title (中): 氮杂胞苷类似物及其用途
-
Application No.: US12238054Application Date: 2008-09-25
-
Publication No.: US08399420B2Publication Date: 2013-03-19
- Inventor: Lewis Silverman , James Holland , Marit Liland Sandvold , Finn Myhren , Ole Henrik Eriksen
- Applicant: Lewis Silverman , James Holland , Marit Liland Sandvold , Finn Myhren , Ole Henrik Eriksen
- Applicant Address: US NY New York NO Oslo
- Assignee: Mount Sanai School of Medicine,Clavis Pharma ASA
- Current Assignee: Mount Sanai School of Medicine,Clavis Pharma ASA
- Current Assignee Address: US NY New York NO Oslo
- Agency: J.A. Lindeman & Co., PLLC
- Main IPC: A01N43/04
- IPC: A01N43/04 ; A61K31/70

Abstract:
The present invention is directed toward compounds of Formula (I) as follows: wherein, R is H, R5C(O), R5CH2OC(O), or R5CH2NHC(O); R1 is where the crossing dashed line illustrates the bond formed joining R1 to the molecule of Formula (I); R2 and R3 are independently OH or H, provided that R2 and R3 are not simultaneously OH; R4 is H, R5C(O), R5CH2OC(O), or R5CH2NHC(O), provided that R and R4 are not simultaneously H; and R5 has the general formula: CH3—(CH2)n—(CH═CH—CH2)m—CH═CH—(CH2)k—; k is an integer from 0 to 7; m is an integer from 0 to 2; and n is an integer from 0 to 10, or a pharmaceutical salt thereof. Methods of making and using these compounds are also disclosed.
Public/Granted literature
- US20090209477A1 AZACYTIDINE ANALOGUES AND USES THEREOF Public/Granted day:2009-08-20
Information query
IPC分类: