Invention Grant
- Patent Title: Method of activation of oxazaphosphorines
- Patent Title (中): 氧氮杂磷的激活方法
-
Application No.: US12375482Application Date: 2007-11-06
-
Publication No.: US08399434B2Publication Date: 2013-03-19
- Inventor: Ivan Spasojevic , Michael O. Colvin , Ines Batinic-Haberle , Susan M. Ludeman , Michael P. Gamcsik
- Applicant: Ivan Spasojevic , Michael O. Colvin , Ines Batinic-Haberle , Susan M. Ludeman , Michael P. Gamcsik
- Applicant Address: US NC Durham
- Assignee: Duke University
- Current Assignee: Duke University
- Current Assignee Address: US NC Durham
- Agency: Myers Bigel Sibley & Sajovec, P.A.
- International Application: PCT/US2007/023359 WO 20071106
- International Announcement: WO2008/073195 WO 20080619
- Main IPC: A01N57/00
- IPC: A01N57/00 ; A61K31/675
Abstract:
The present invention provides a method of hydroxylating or oxidizing a compound of interest in a subject (e.g., a cytotoxic oxazaphosphorine prodrug), by administering the compound of interest to the subject; and concurrently administering the subject a metalloporphyrin in an amount effective to hydroxylate or oxidize the compound of interest in the subject.
Public/Granted literature
- US20120077782A9 METHOD OF ACTIVATION OF OXAZAPHOSPHORINES Public/Granted day:2012-03-29
Information query
