Invention Grant
- Patent Title: Fused heterocyclic derivative and use thereof
- Patent Title (中): 熔融杂环衍生物及其用途
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Application No.: US12919413Application Date: 2009-02-25
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Publication No.: US08399449B2Publication Date: 2013-03-19
- Inventor: Nobuhiro Fujii , Yuya Oguro , Satoshi Sasaki , Shigeru Kondo
- Applicant: Nobuhiro Fujii , Yuya Oguro , Satoshi Sasaki , Shigeru Kondo
- Applicant Address: JP Osaka
- Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee Address: JP Osaka
- Agency: Hamre, Schumann, Mueller & Larson, P.C.
- Priority: JP2008-045134 20080226; JP2008-256755 20081001
- International Application: PCT/JP2009/054007 WO 20090225
- International Announcement: WO2009/107850 WO 20090903
- Main IPC: A61K31/4375
- IPC: A61K31/4375 ; A61K31/4355 ; A61K31/4365 ; A61K31/437 ; A61K31/438 ; A61K31/496 ; A61K31/497 ; A61K31/506 ; A61K31/5377 ; A61K31/541 ; A61K31/55 ; A61K31/551 ; A61P35/00 ; C07D471/04 ; C07D471/14 ; C07D491/10 ; C07D495/04
Abstract:
The present invention provides a compound having a superior Smo inhibitory activity and lower toxicity, which is sufficiently satisfactory as a pharmaceutical product. The present invention provides a compound represented by the formula (I) wherein ring A is 5- to 7-membered ring optionally having substituent(s), where substituents are optionally bonded to each other to form a ring; X is O, S or NR1 (R1 is a hydrogen atom or a hydrocarbon group optionally having substituent(s)); R2 is carbamoyl optionally having substituent(s); and R3 is hydroxy optionally having substituent(s), or a salt thereof.
Public/Granted literature
- US20110003788A1 FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF Public/Granted day:2011-01-06
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