Invention Grant
- Patent Title: Heterocyclic compounds
- Patent Title (中): 杂环化合物
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Application No.: US12850892Application Date: 2010-08-05
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Publication No.: US08399451B2Publication Date: 2013-03-19
- Inventor: John L. Gilmore , James E. Sheppeck
- Applicant: John L. Gilmore , James E. Sheppeck
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Gary D. Greenblatt
- Main IPC: A61K31/4245
- IPC: A61K31/4245 ; A61K31/454 ; A61K31/4439 ; A61K31/506 ; A61K31/4545 ; A61K31/5377 ; A61K31/497 ; C07D413/14 ; C07D413/04 ; C07D417/14

Abstract:
Disclosed are compounds of Formula (I) or a stereoisomer or a pharmaceutically acceptable salt thereof, wherein: A is Q is a substituted 5-membered monocyclic heteroaryl group; W is CH2, O, or NH; and R1, R2, R3, R4, R5, R6, m, n, t, and x are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
Public/Granted literature
- US20110190255A1 HETEROCYCLIC COMPOUNDS Public/Granted day:2011-08-04
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