Invention Grant
US08399473B2 Macrocyclic spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease
有权
用于治疗阿尔茨海默氏病的大环螺哌啶β-分泌酶抑制剂
- Patent Title: Macrocyclic spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease
- Patent Title (中): 用于治疗阿尔茨海默氏病的大环螺哌啶β-分泌酶抑制剂
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Application No.: US12443088Application Date: 2007-10-02
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Publication No.: US08399473B2Publication Date: 2013-03-19
- Inventor: Philippe G Nantermet , M. Katharine Holloway , Keith P. Moore , Shaun R. Stauffer
- Applicant: Philippe G Nantermet , M. Katharine Holloway , Keith P. Moore , Shaun R. Stauffer
- Applicant Address: US NJ Rahway
- Assignee: Merck, Sharp & Dohme, Corp.
- Current Assignee: Merck, Sharp & Dohme, Corp.
- Current Assignee Address: US NJ Rahway
- Agent Keith D. MacMillan; Gerard M. Devlin
- International Application: PCT/US2007/021207 WO 20071002
- International Announcement: WO2008/045250 WO 20080417
- Main IPC: A61K31/438
- IPC: A61K31/438 ; C07D471/20 ; A61P25/28
Abstract:
The present invention is directed to compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
Public/Granted literature
- US20100029701A1 MACROCYCLIC SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE Public/Granted day:2010-02-04
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