Invention Grant
US08399504B2 Carbamate and urea inhibitors of 11Beta-hydroxysteroid dehydrogenase 1
失效
11β-羟基类固醇脱氢酶的氨基甲酸酯和尿素抑制剂1
- Patent Title: Carbamate and urea inhibitors of 11Beta-hydroxysteroid dehydrogenase 1
- Patent Title (中): 11β-羟基类固醇脱氢酶的氨基甲酸酯和尿素抑制剂1
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Application No.: US12988374Application Date: 2009-04-21
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Publication No.: US08399504B2Publication Date: 2013-03-19
- Inventor: David A. Claremon , Linghang Zhuang , Yuanjie Ye , Suresh B. Singh , Colin M. Tice
- Applicant: David A. Claremon , Linghang Zhuang , Yuanjie Ye , Suresh B. Singh , Colin M. Tice
- Applicant Address: US PA Fort Washington
- Assignee: Vitae Pharmaceuticals, Inc.
- Current Assignee: Vitae Pharmaceuticals, Inc.
- Current Assignee Address: US PA Fort Washington
- Agency: McCarter & English, LLP
- Agent Steven G. Davis; Michael J. DeGrazia
- International Application: PCT/US2009/002478 WO 20090421
- International Announcement: WO2009/131669 WO 20091029
- Main IPC: A61K31/40
- IPC: A61K31/40
Abstract:
This invention relates to novel compounds of the Formula (I) pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds of the Formula (I) and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.
Public/Granted literature
- US20110112062A1 Carbamate And Urea Inhibitors Of 11Beta-Hydroxysteroid Dehydrogenase 1 Public/Granted day:2011-05-12
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