Invention Grant
US08399523B2 Quarternization of the additive amino alkylmethacrylate copolymer E for improving permeability and solubility of pharmaceuticals
有权
氨基甲基丙烯酸烷基酯共聚物E的改性，用于提高药物的渗透性和溶解度
- Patent Title: Quarternization of the additive amino alkylmethacrylate copolymer E for improving permeability and solubility of pharmaceuticals
- Patent Title (中): 氨基甲基丙烯酸烷基酯共聚物E的改性，用于提高药物的渗透性和溶解度
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Application No.: US12747722Application Date: 2008-12-12
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Publication No.: US08399523B2Publication Date: 2013-03-19
- Inventor: Peter Langguth , Stefan Grube , Holger Frey , Boris Obermeier
- Applicant: Peter Langguth , Stefan Grube , Holger Frey , Boris Obermeier
- Applicant Address: DE Darmstadt
- Assignee: Evonik Roehm GmbH
- Current Assignee: Evonik Roehm GmbH
- Current Assignee Address: DE Darmstadt
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: DE102007060175 20071213
- International Application: PCT/EP2008/010585 WO 20081212
- International Announcement: WO2009/074336 WO 20090618
- Main IPC: A61K47/32
- IPC: A61K47/32 ; C08F26/02
Abstract:
The present invention relates to a strategy for improving the permeability and solubility of pharmaceuticals, based on adding a chemically modified amino alkyl methacrylate copolymer E, wherein the chemical modification is the quaternization of a fraction of the existing amino alkyl groups.
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