Invention Grant
US08399646B2 Isolated nucleic acid encoding an antibody which specifically binds to PCSK9 and a host cell that produces the antibody
有权
编码与PCSK9特异性结合的抗体的分离的核酸和产生抗体的宿主细胞
- Patent Title: Isolated nucleic acid encoding an antibody which specifically binds to PCSK9 and a host cell that produces the antibody
- Patent Title (中): 编码与PCSK9特异性结合的抗体的分离的核酸和产生抗体的宿主细胞
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Application No.: US13225119Application Date: 2011-09-02
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Publication No.: US08399646B2Publication Date: 2013-03-19
- Inventor: Hong Liang , Yasmina Noubia Abdiche , Javier Fernando Chaparro Riggers , Bruce Charles Gomes , Julie Jia Li Hawkins , Jaume Pons , Yuli Wang
- Applicant: Hong Liang , Yasmina Noubia Abdiche , Javier Fernando Chaparro Riggers , Bruce Charles Gomes , Julie Jia Li Hawkins , Jaume Pons , Yuli Wang
- Applicant Address: US CA South San Francisco US NY New York
- Assignee: Rinat Neuroscience Corp.,Pfizer Inc.
- Current Assignee: Rinat Neuroscience Corp.,Pfizer Inc.
- Current Assignee Address: US CA South San Francisco US NY New York
- Agency: Pfizer Inc.
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12P21/08 ; C12N5/07
Abstract:
The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acid. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease, including treatment of hypercholesterolemia.
Public/Granted literature
- US20120015435A1 PCSK9 ANTAGONISTS Public/Granted day:2012-01-19
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