Invention Grant
US08399649B2 Methods of detecting and controlling mucoid Pseudomonas biofilm production
有权
检测和控制粘液样假单胞菌生物膜生产的方法
- Patent Title: Methods of detecting and controlling mucoid Pseudomonas biofilm production
- Patent Title (中): 检测和控制粘液样假单胞菌生物膜生产的方法
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Application No.: US12819770Application Date: 2010-06-21
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Publication No.: US08399649B2Publication Date: 2013-03-19
- Inventor: Hongwei D. Yu , Dongru Qiu
- Applicant: Hongwei D. Yu , Dongru Qiu
- Applicant Address: US WV Huntington
- Assignee: Marshall University Research Corporation
- Current Assignee: Marshall University Research Corporation
- Current Assignee Address: US WV Huntington
- Agency: Stites & Harbison PLLC
- Agent Terry L. Wright
- Main IPC: C07H21/00
- IPC: C07H21/00
Abstract:
Compositions and methods for detecting and controlling the conversion to mucoidy in Pseudomonas aeruginosa are disclosed. The present invention provides for detecting the switch from nonmucoid to mucoid state of P. aeruginosa by measuring mucE expression or MucE protein levels. The interaction between MucE and AlgW controls the switch to mucoidy in wild type P. aeruginosa. Also disclosed is an alginate biosynthesis heterologous expression system for use in screening candidate substances that inhibit conversion to mucoidy.
Public/Granted literature
- US20110008786A1 METHODS OF DETECTING AND CONTROLLING MUCOID PSEUDOMONAS BIOFILM PRODUCTION Public/Granted day:2011-01-13
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