Invention Grant
US08399655B2 Process and methods for the preparation of optically active cis-2-hydroxymethyl-4-(cytosin-1′-yl)-1,3-oxathiolane or pharmaceutically acceptable salts thereof
有权
用于制备光学活性顺式-2-羟甲基-4-（细胞蛋白酶-1'-基）-1,3-氧硫杂环戊烷的方法和方法或其药学上可接受的盐
- Patent Title: Process and methods for the preparation of optically active cis-2-hydroxymethyl-4-(cytosin-1′-yl)-1,3-oxathiolane or pharmaceutically acceptable salts thereof
- Patent Title (中): 用于制备光学活性顺式-2-羟甲基-4-（细胞蛋白酶-1'-基）-1,3-氧硫杂环戊烷的方法和方法或其药学上可接受的盐
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Application No.: US13166242Application Date: 2011-06-22
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Publication No.: US08399655B2Publication Date: 2013-03-19
- Inventor: Alex Cimpoia , Dan Simion
- Applicant: Alex Cimpoia , Joana R. Simion
- Applicant Address: CA Laval, Quebec
- Assignee: SHIRE Canada Inc.
- Current Assignee: SHIRE Canada Inc.
- Current Assignee Address: CA Laval, Quebec
- Agency: Millen, White, Zelano & Branigan, P.C.
- Main IPC: C07D411/04
- IPC: C07D411/04 ; C07D239/47 ; A61K31/506 ; A61K31/513 ; A61K31/7072 ; A61P31/18
Abstract:
There is provided a method for resolving a compound of formula III, in the cis configuration: There is also provided a process for producing optically active compound of formula I or II: wherein: R1, R2, R3 are as defined herein, the method and process involving the production, recovery and conversion of diastereomeric salts.
Public/Granted literature
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