Invention Grant
US08404236B2 Method of identifying membrane Ig specific antibodies and use thereof for targeting immunoglobulin-producing precursor cells
有权
鉴定膜Ig特异性抗体的方法及其用于靶向产生免疫球蛋白的前体细胞的用途
- Patent Title: Method of identifying membrane Ig specific antibodies and use thereof for targeting immunoglobulin-producing precursor cells
- Patent Title (中): 鉴定膜Ig特异性抗体的方法及其用于靶向产生免疫球蛋白的前体细胞的用途
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Application No.: US13372170Application Date: 2012-02-13
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Publication No.: US08404236B2Publication Date: 2013-03-26
- Inventor: Herren Wu , Peter Kiener , Partha S. Chowdhury , James F. Young
- Applicant: Herren Wu , Peter Kiener , Partha S. Chowdhury , James F. Young
- Applicant Address: US MD Gaithersburg
- Assignee: MedImmune, LLC
- Current Assignee: MedImmune, LLC
- Current Assignee Address: US MD Gaithersburg
- Agency: MedImmune, LLC
- Main IPC: A61K39/00
- IPC: A61K39/00
Abstract:
The present invention relates to the discovery of antibodies that bind to novel epitopes present on membrane-anchored immunoglobulins and which bind to these novel epitopes on the surface of B cells and plasma cells. In addition, the antibodies of the present invention can mediate ADCC and can be useful to deplete those B cells and plasma cells expressing the novel epitopes of the invention. The antibodies of the present invention can be useful for the treatment of B cell-mediated diseases and diseases caused by monoclonal expansion of B cells. Accordingly the present invention also provides compositions and methods for the prevention, management, treatment or amelioration of B cell-mediated diseases and diseases caused by monoclonal expansion of B cells.
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