Invention Grant
US08404666B2 2-substituted-1α,25-dihydroxy-19,26,27-trinor vitamin D analogs and uses thereof
有权
2-取代-1α,25-二羟基-19,26,27-三核维生素D类似物及其用途
- Patent Title: 2-substituted-1α,25-dihydroxy-19,26,27-trinor vitamin D analogs and uses thereof
- Patent Title (中): 2-取代-1α,25-二羟基-19,26,27-三核维生素D类似物及其用途
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Application No.: US11697434Application Date: 2007-04-06
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Publication No.: US08404666B2Publication Date: 2013-03-26
- Inventor: Hector F. DeLuca , Lori A. Plum , Margaret Clagett-Dame , Pawel Grzywacz
- Applicant: Hector F. DeLuca , Lori A. Plum , Margaret Clagett-Dame , Pawel Grzywacz
- Applicant Address: US WI Madison
- Assignee: Wisconsin Alumni Research Foundation
- Current Assignee: Wisconsin Alumni Research Foundation
- Current Assignee Address: US WI Madison
- Agency: Andrus, Sceales, Starke & Sawall, LLP
- Main IPC: A61K31/59
- IPC: A61K31/59 ; C07C401/00

Abstract:
Compounds of formula I, II or III are provided where X1, X2 and X3 are independently selected from H and hydroxy protecting groups and R1 and R2 are independently selected from H or straight or branched chain alkyl groups having from 1 to 8 carbon atoms, straight or branched chain alkenyl groups having from 2 to 8 carbon atoms, straight or branched chain hydroxy-substituted alkyl groups having from 1 to 8 carbon atoms, or straight and branched chain hydroxy-substituted alkenyl groups having from 2 to 8 carbon atoms; and R3 is independently selected from straight or branched chain alkyl groups having from 1 to 8 carbon atoms, straight or branched chain alkenyl groups having from 2 to 8 carbon atoms, straight or branched chain hydroxy-substituted alkyl groups having from 1 to 8 carbon atoms, or straight and branched chain hydroxy-substituted alkenyl groups having from 2 to 8 carbon atoms. Such compounds are used in preparing pharmaceutical compositions and are useful in treating a variety of biological conditions.
Public/Granted literature
- US20070238704A1 2-Substituted-1Alpha,25-Dihydroxy-19,26,27-Trinor Vitamin D Analogs and Uses Thereof Public/Granted day:2007-10-11
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