Invention Grant
US08404680B2 N-[3-(5-amino-3,3a,7,7a-tetrahydro-1H-2,4-dioxa-6-aza-inden-7-yl)-phenyl]-amides as BACE1 and/or BACE2 inhibitors
有权
作为BACE1和/或BACE2抑制剂的N- [3-（5-氨基-3,3a，7,7a-四氢-1H-2,4-二氧杂-6-氮杂 - 茚-7-基） - 苯基]酰胺
![N-[3-(5-amino-3,3a,7,7a-tetrahydro-1H-2,4-dioxa-6-aza-inden-7-yl)-phenyl]-amides as BACE1 and/or BACE2 inhibitors](/docs/US/2013-03-26/US08404680B2/abs.jpg.600x600.jpg)
- Patent Title: N-[3-(5-amino-3,3a,7,7a-tetrahydro-1H-2,4-dioxa-6-aza-inden-7-yl)-phenyl]-amides as BACE1 and/or BACE2 inhibitors
- Patent Title (中): 作为BACE1和/或BACE2抑制剂的N- [3-（5-氨基-3,3a，7,7a-四氢-1H-2,4-二氧杂-6-氮杂 - 茚-7-基） - 苯基]酰胺
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Application No.: US13364672Application Date: 2012-02-02
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Publication No.: US08404680B2Publication Date: 2013-03-26
- Inventor: Hans Hilpert , Roland Humm
- Applicant: Hans Hilpert , Roland Humm
- Applicant Address: US NJ Nutley
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Nutley
- Agent George W. Johnston; Patricia S. Rocha-Tramaloni; Kimberly J. Prior
- Priority: EP11153633 20110208
- Main IPC: C07D498/04
- IPC: C07D498/04 ; A61K31/5365
![N-[3-(5-amino-3,3a,7,7a-tetrahydro-1H-2,4-dioxa-6-aza-inden-7-yl)-phenyl]-amides as BACE1 and/or BACE2 inhibitors](/abs-image/US/2013/03/26/US08404680B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to N-[3-(5-Amino-3,3a,7,7a-tetrahydro-1H-2,4-dioxa-6-aza-inden-7-yl)-phenyl]-amides of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
Public/Granted literature
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